Ask the Expert: Restylane Defyne and Refyne Injectables | ageistbeauty

Ask the Expert: Restylane Defyne and Refyne Injectables

Restylane recently launched two new injectables (Defyne and Refyne) for use on wrinkles and folds around the mouth. Frankly, the injectables landscape feels so crowded I wasn’t clear on what the difference was between the new products versus standard Restylane and other dermal fillers such as Bellafill, Juvederm and Perlane. So, I checked in with Dr. Michelle Henry, a board-certified dermatologist based in New York City, to get the real story.

What is the difference between Restylane Defyne and Refyne?

Refyne was approved to treat moderate wrinkles and folds from the nose to mouth, while Defyne is meant to plump and fill deep-set lines.  Simply put, Refyne is typically used more superficially and Defyne at a deeper plane.

What makes both of them different from other dermal fillers on the market?

The new technology is called XpresHA which allows the hyaluronic acid gel to be more flexible within the skin.  It moves fluidly with the skin when the patient is smiling, frowning, or animating in any way allowing for a natural, not ridged appearance.

Are there benefits to having fillers that only last up to 12 months?

There is a commonly used phrase in dermatology that states, “permanent filler equals permanent problems.” In addition, any object that lasts forever can act as a nidus for infection. Further, aging is dynamic and there are very few occasions when a fixed implant looks great over the course of one’s life.  Typically, adjustments need to be made to maintain a natural appearance.

Is there any difference in the way that Restylane Defyne and Refyne are injected?

Although the technology used to formulate Refyne and Defyne is new, the injection technique is the same.  Refyne and Defyne are injected using the same techniques as other fillers used in moderate and deep wrinkles.  Physicians comfortable with older fillers should have no problem adopting this line.

Is there any post-treatment swelling, bruising or pain?

There might be some bruising or swelling lasting from 2-7 days.  The duration of the bruising or swelling depends on the area treated and the technique used for placement of the product.  Typically, there is very little a pain after the procedure. On occasion, patients report slight tenderness for about 24 hours at the injection site.  This is typically not bothersome and is only reported upon inquiry.

Who is the ideal candidate for these fillers?

Anyone with signs of aging and wrinkling in areas that are prone to having motion and expression (e.g. nasolabial, accessory smile lines and marionette lines).

What is the average cost for the treatment?

On average, I use 1-2 syringes per treatment.  The cost is similar to other fillers and can range from $700 – $1,600.


Dr. Michelle Henry is a Harvard trained, board certified dermatologist.  She is currently a Clinical Instructor of Dermatology at Weill Cornell Medical College. She practices Mohs micrographic surgery, laser surgery, and cosmetic surgery. She is a fellow of the American Academy of Dermatology, American Society of Dermatologic Surgery, American Society for Laser Medicine, and American College of Mohs Surgery. Dr. Henry has also been featured in many magazine and newspaper publications, including Instyle, Cosmopolitan, Woman’s Day, Essence and Newsday. Her treatment philosophy is to provide holistic care while utilizing the latest techniques and scientific data.

To learn more about Dr. Henry, visit

2 years ago by in Cosmetic Surgery , Facial Treatments | You can follow any responses to this entry through the RSS feed. You can leave a response, or trackback from your own site.
About the

By day, I am a busy marketing executive, mother of a 9 year-old daughter, and wife. At night, I put on my cool black eyeglasses, Stila Fiery long-wearing lipstick and become Ageist Beauty, a makeup, skincare and anti-aging product-obsessed beauty blogger with a particular passion for minimizing the pores of women across the globe.

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